Patin, Emmanuel C; Willcocks, Sam; Orr, Selinda; Ward, Theresa H; Lang, Roland; Schaible, Ulrich E; (2016) Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro. Innate immunity, 22 (3). pp. 181-185. ISSN 1753-4259 DOI: https://doi.org/10.1177/1753425916636671
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Abstract
The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
Item Type | Article |
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Faculty and Department | Faculty of Infectious and Tropical Diseases > Department of Infection Biology |
PubMed ID | 26939595 |
ISI | 373228700005 |
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