Pocock, Stuart J; Clayton, Tim C; Stone, Gregg W; (2015) Design of Major Randomized Trials: Part 3 of a 4-Part Series on Statistics for Clinical Trials. Journal of the American College of Cardiology, 66 (24). pp. 2757-2766. ISSN 0735-1097 DOI: https://doi.org/10.1016/j.jacc.2015.10.036
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Abstract
This paper provides practical guidance on the fundamentals of design for major randomized controlled trials. Topics covered include the choice of patients, choice of treatment and control groups, choice of primary and secondary endpoints, methods of randomization, appropriate use of blinding, and determination of trial size. Insights are made with reference to contemporary major trials in cardiology.
Item Type | Article |
---|---|
Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Medical Statistics |
Research Centre | ?? 208138 ?? |
PubMed ID | 26700838 |
ISI | 366312500011 |
Downloads
Filename: JACC3_LSHTM_1.pdf
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0
DownloadFilename: JACC3 fig 1.pdf
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0
DownloadFilename: JACC3 fig 2.pdf
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0
Download