Perry, Daniel C;
Hall, Andrew J;
(2011)
The epidemiology and etiology of Perthes disease.
The Orthopedic clinics of North America, 42 (3).
279-v.
ISSN 0030-5898
DOI: https://doi.org/10.1016/j.ocl.2011.03.002
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The incidence of Perthes disease varies markedly both between countries and within countries down to a local level. The disease is more common in white than in Asian or black African children. The disease is associated with deprivation; with a steep disease gradient across social class groups. This epidemiology alongside the lack of concordance in twins suggests a strong environmental etiology, with little evidence to suggest a genetic predisposition. Children are frequently short, with a growth pattern described as "rostral-sparing". A propensity to associated congenital anomalies suggests an intrauterine cause.