High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa.

Inzaule, Seth C; Jordan, Michael R; Bello, George; Wadonda-Kabondo, Nellie; Mounerou, Salou; Mbulli, Innocent A; Akanmu, Sulaimon A; Vubil, Adolfo; Hunt, Gillian; Kaleebu, Pontiano; +8 more... Mthethwa-Hleza, Simangele; Dzangare, Janet; Njukeng, Patrick; Penazzato, Martina; Rinke de Wit, Tobias F; Eshleman, Susan H; Bertagnolio, Silvia; Infant HIV Drug Resistance Survey Team; (2020) High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa. AIDS (London, England), 34 (10). pp. 1567-1570. ISSN 0269-9370 DOI: https://doi.org/10.1097/QAD.0000000000002580

Abstract

: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.