High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa.
Inzaule, Seth C;
Jordan, Michael R;
Bello, George;
Wadonda-Kabondo, Nellie;
Mounerou, Salou;
Mbulli, Innocent A;
Akanmu, Sulaimon A;
Vubil, Adolfo;
Hunt, Gillian;
Kaleebu, Pontiano;
+8 more...Mthethwa-Hleza, Simangele;
Dzangare, Janet;
Njukeng, Patrick;
Penazzato, Martina;
Rinke de Wit, Tobias F;
Eshleman, Susan H;
Bertagnolio, Silvia;
Infant HIV Drug Resistance Survey Team;
(2020)
High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa.
AIDS (London, England), 34 (10).
pp. 1567-1570.
ISSN 0269-9370
DOI: https://doi.org/10.1097/QAD.0000000000002580
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: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.