Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes.

Mesher, David; Soldan, Kate; Lehtinen, Matti; Beddows, Simon; Brisson, Marc; Brotherton, Julia ML; Chow, Eric PF; Cummings, Teresa; Drolet, Mélanie; Fairley, Christopher K; +11 more... Garland, Suzanne M; Kahn, Jessica A; Kavanagh, Kimberley; Markowitz, Lauri; Pollock, Kevin G; Söderlund-Strand, Anna; Sonnenberg, Pam; Tabrizi, Sepehr N; Tanton, Clare; Unger, Elizabeth; Thomas, Sara L; (2016) Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes. Emerging infectious diseases, 22 (10). pp. 1732-1740. ISSN 1080-6040 DOI: https://doi.org/10.3201/eid2210.160675

Abstract

We analyzed human papillomavirus (HPV) prevalences during prevaccination and postvaccination periods to consider possible changes in nonvaccine HPV genotypes after introduction of vaccines that confer protection against 2 high-risk types, HPV16 and HPV18. Our meta-analysis included 9 studies with data for 13,886 girls and women ≤19 years of age and 23,340 women 20-24 years of age. We found evidence of cross-protection for HPV31 among the younger age group after vaccine introduction but little evidence for reductions of HPV33 and HPV45. For the group this same age group, we also found slight increases in 2 nonvaccine high-risk HPV types (HPV39 and HPV52) and in 2 possible high-risk types (HPV53 and HPV73). However, results between age groups and vaccines used were inconsistent, and the increases had possible alternative explanations; consequently, these data provided no clear evidence for type replacement. Continued monitoring of these HPV genotypes is important.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Public Health and Policy > Dept of Global Health and Development Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID	27648688
ISI	384387400005
Related URLs	OA Location