Antiretroviral therapy abrogates association between arginase activity and HIV disease severity.
Cloke, TE;
Abebe, T;
Hailu, A;
Munder, M;
Taylor, GP;
Müller, I;
Kropf, P;
(2010)
Antiretroviral therapy abrogates association between arginase activity and HIV disease severity.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 104 (11).
pp. 746-748.
ISSN 0035-9203
DOI: https://doi.org/10.1016/j.trstmh.2010.08.004
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Arginase-induced L-arginine deprivation is emerging as a key mechanism for the downregulation of immune responses. We hypothesised that arginase activity increases with disease severity in HIV-seropositive patients. Our results show that peripheral blood mononuclear cells (PBMCs) from 23 HIV-seropositive patients with low CD4(+) T cell counts (≤350 cells/μl) expressed significantly more arginase compared with 21 patients with high CD4(+) T cell counts. Furthermore, we found a significant association between the two principal prognostic markers used to monitor HIV disease (CD4(+) T cell count and plasma viral load) and PBMC arginase activity in antiretroviral therapy naïve patients but not in patients undergoing therapy.