Invasive cervical cancer and human immunodeficiency virus (HIV) infection: a South African perspective


Moodley, M; Moodley, J; Kleinschmidt, I; (2001) Invasive cervical cancer and human immunodeficiency virus (HIV) infection: a South African perspective. International journal of gynecological cancer, 11 (3). pp. 194-7. ISSN 1048-891X DOI: https://doi.org/10.1046/j.1525-1438.2001.01022.x

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Abstract

The aim of this study was to compare the prevalence and presentation of cervical cancer in HIV-positive and HIV-negative women in our local population. Six hundred and seventy-two patients with cervical cancer presented to the gynecology oncology unit of King Edward VIII Hospital, South Africa. The HIV seroprevalence among these patients was 21%. There was an increase in the background prevalence of HIV infection (1.6-32.5%) as well as a quadrupling in the prevalence of HIV infection among patients with invasive cervical cancer (5-21%) over a 10-year period. The mean ages of the HIV-negative patients and HIV-positive patients were 55.2 and 39.8 years, respectively. Most of the HIV-positive patients were in the 30- to 40-year-old age group (51%), whereas the majority of patients who were HIV negative were in the 50- to 60-year-old age group (36%). The majority of patients, irrespective of HIV status, were more likely to have late stage disease than early stage disease. There was an increase in HIV infection in patients with both types of background prevalence and among patients with invasive cervical cancer. The mean age of HIV-positive patients was 15 years younger than that of the HIV-negative patients. The majority of patients, irrespective of HIV status, presented with late stage disease.

Item Type: Article
Keywords: Adult, Age Factors, Carcinoma, Squamous Cell/*epidemiology/pathology, Female, HIV Infections/*epidemiology, Humans, Middle Aged, Neoplasm Staging, Prospective Studies, Seroepidemiologic Studies, South Africa/epidemiology, Uterine Cervical Neoplasms/*epidemiology/pathology, Adult, Age Factors, Carcinoma, Squamous Cell, epidemiology, pathology, Female, HIV Infections, epidemiology, Humans, Middle Aged, Neoplasm Staging, Prospective Studies, Seroepidemiologic Studies, South Africa, epidemiology, Uterine Cervical Neoplasms, epidemiology, pathology
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 11437924
Web of Science ID: 169693200005
URI: http://researchonline.lshtm.ac.uk/id/eprint/9962

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