The relationship of impulsivity to response inhibition and decision-making in remitted patients with bipolar disorder.


Christodoulou, T; Lewis, M; Ploubidis, GB; Frangou, S; (2006) The relationship of impulsivity to response inhibition and decision-making in remitted patients with bipolar disorder. European psychiatry, 21 (4). pp. 270-3. ISSN 0924-9338 DOI: https://doi.org/10.1016/j.eurpsy.2006.04.006

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Abstract

BACKGROUND: Impulsivity, a core feature of bipolar disorder (BD), is a multifaceted concept encompassing failure of response inhibition and poor decision-making. Abnormalities in these two cognitive domains have been reported in BD patients but their relationship with impulsivity has not been explored. METHODS: Twenty-five remitted patients with BD completed the Barratt Impulsiveness Scale (BIS) and performed the Hayling Sentence Completion Task (HSCT) and a computerized version of the Iowa Gambling task. The HSCT total errors scaled score was used as a measure of response inhibition while the gabling task score, which reflects participants' ability to make advantageous choices, was used a measure of decision making. RESULTS: Higher scores on the BIS attentional and non-planning subscales were respectively associated with more errors in the HSCT and less advantageous choices in the gambling task. LIMITATIONS: All patients were medicated. Healthy participants were not included. CONCLUSIONS: Viewed in the context of recent relevant studies our findings suggest that impulsivity, response inhibition and decision-making in BD may represent behavioural manifestations of the same underlying biological mechanism possibly linked to ventral prefrontal cortical function.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Population Studies (1974-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
PubMed ID: 16762532
Web of Science ID: 239032900010
URI: http://researchonline.lshtm.ac.uk/id/eprint/9948

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