Frequent feeding delays the gastric emptying of a subsequent meal


Jackson, SJ; Leahy, FE; Jebb, SA; Prentice, AM; Coward, WA; Bluck, LJC; (2007) Frequent feeding delays the gastric emptying of a subsequent meal. Appetite, 48 (2). pp. 199-205. ISSN 0195-6663 DOI: https://doi.org/10.1016/j.appet.2006.09.003

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Abstract

To assess the suitability of the 13 C-octanoic acid breath test for measuring gastric emptying in circumstances other than the post-absorptive state, a preliminary study was performed where 6 hourly spaced isoenergetic meals preceded the determination of gastric emptying of a subsequent 2 MJ meal. Emptying was measured in three individuals on four separate occasions, with a reproducibility of 8%. A crossover study was then conducted to test the hypothesis that meal frequency can modulate the gastric emptying of a subsequent meal, with the potential to influence appetite regulation. Sixteen subjects were fed to energy balance, receiving food either as 2 isoenergetic meals 3 It apart or 6 isoenergetic meals fed hourly. Gastric emptying of a subsequent 2 MJ meal was investigated. Visual analogue scales were used throughout to assess appetite. The maximum rate of gastric emptying was unchanged but the onset of emptying was delayed by the more frequent feeding pattern. There was no significant difference in subjective appetite before or after the test meal. In conclusion, short-term increases in feeding frequency delayed the gastric emptying of a subsequent meal, but significant effects on post-meal appetite could not be demonstrated. (c) 2006 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: C-13 octanoic acid breath test, frequent feeding, gastric emptying, ACID BREATH TEST, LABELED OCTANOIC-ACID, SNACKING PATTERNS, LIPID, PROFILES, SOLIDS, APPETITE, OBESE, REPRODUCIBILITY, SCINTIGRAPHY, WOMEN, Adult, Appetite, physiology, Breath Tests, Carbon Isotopes, Cross-Over Studies, Eating, Gastric Emptying, physiology, Humans, Male, Middle Aged, Octanoic Acids, diagnostic use, Time Factors
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 17081656
Web of Science ID: 244648500011
URI: http://researchonline.lshtm.ac.uk/id/eprint/9711

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