Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall study


Clarke, R; Shipley, M; Breeze, E; Collins, R; Marmot, M; Halsey, J; Fletcher, A; Hemingway, H; (2007) Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall study. European journal of cardiovascular prevention and rehabilitation, 14 (2). pp. 280-286. ISSN 1741-8267 DOI: https://doi.org/10.1097/01.hjr.0000214602.68619.05

Full text not available from this repository.

Abstract

Background While the excess mortality associated with a diagnosis of angina, myocardial infarction in middle-aged individuals is well established, there is little available evidence on the natural history of angina in population-based studies of older people. Design We conducted a 5-year follow-up of 6655 older men aged 67-90 years (mean age 77 years) who participated in the Whitehall Study of London Civil Servants. Methods Survival was examined in relation to a diagnosis of angina or myocardial infarction and to angina symptoms in a population-based study of older men living in the United Kingdom in the late 1990s. Results Compared with men without a diagnosis of myocardial ischaemia n=5219), a diagnosis of angina alone (n=617), myocardial infarction alone (n=421) or both (n=398) were associated with about a threefold, fourfold and sixfold higher risk of death from coronary heart disease, respectively. Median expectation of life at age 70 years was reduced by about 2, 5 and 6 years for those with angina, myocardial infarction, or both, respectively. Current symptoms of angina among those without previously diagnosed angina, was associated with a 2-fold higher risk of coronary heart disease mortality than those without either diagnosis or symptoms. Conclusions Both angina symptoms and diagnosis have a significant adverse effect on survival among men aged 70-90 years highlighting the importance of diagnosis and appropriate treatment of angina in old age.

Item Type: Article
Keywords: angina, myocardial infarction, risk factors, mortality, RANDOMIZED CONTROLLED-TRIAL, CORONARY-ARTERY-DISEASE, ISCHEMIC-HEART-DISEASE, STABLE ANGINA, NATURAL-HISTORY, MYOCARDIAL-INFARCTION, CIVIL-SERVANTS, RISK-FACTORS, ROSE ANGINA, FOLLOW-UP
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 17446808
Web of Science ID: 245958000017
URI: http://researchonline.lshtm.ac.uk/id/eprint/9567

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
316Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item