Associations of gestational age and intrauterine growth with systolic blood pressure in a family-based study of 386 485 men in 331 089 families


Lawlor, DA; Hubinette, A; Tynelius, P; Leon, DA; Smith, GD; Rasmussen, F; (2007) Associations of gestational age and intrauterine growth with systolic blood pressure in a family-based study of 386 485 men in 331 089 families. Circulation, 115 (5). pp. 562-568. ISSN 0009-7322 DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.646661

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Abstract

Background - We conducted a family-based study to explore mechanisms underlying the associations of birth weight and gestational age with systolic blood pressure measured at 17 to 19 years of age. Methods and Results - A record linkage study of 386 485 singleton-born men from 331 089 families was undertaken. Birth weight was inversely associated with systolic blood pressure within siblings, with a mean difference (adjusted for age at examination, examination center, and year of examination) within siblings per 1-SD difference in birth weight of -0.21 mm Hg (95% CI, -0.33 to -0.08) and between nonsiblings of -0.12 (95% CI, -0.16 to -0.08). Gestational age was inversely associated with systolic blood pressure within siblings (-0.18 mm Hg; 95% CI, -0.25 to -0.11, per week of gestational age) and between nonsiblings (-0.26 mm Hg; 95% CI, -0.29 to -0.24). Adjustment for socioeconomic position and maternal characteristics did not alter these within- or between-family associations. Furthermore, the associations were not affected by adjustment for paternal height, body mass index, or systolic blood pressure. Conclusions - Our present findings suggest that the inverse associations of birth weight and gestational age with systolic blood pressure are not explained by confounding resulting from family socioeconomic position or other factors that are shared by siblings. Variations in maternal metabolic or vascular health during pregnancy or placental implantation and function may explain these associations.

Item Type: Article
Keywords: birth weight, blood pressure, epidemiology, fetal development, pediatrics, CORONARY-HEART-DISEASE, FETAL ORIGINS HYPOTHESIS, BIRTH-WEIGHT, ABERDEEN CHILDREN, CHILDHOOD GROWTH, SIBLING PAIRS, 1950S COHORT, IN-UTERO, ADULTS, INTELLIGENCE, Adolescent, Adult, Birth Weight, physiology, Blood Pressure, physiology, Body Weight, physiology, Cohort Studies, Family, Fetal Development, physiology, Gestational Age, Humans, Male
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: ECOHOST - The Centre for Health and Social Change
Centre for Maternal, Reproductive and Child Health (MARCH)
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 17242278
Web of Science ID: 244000800007
URI: http://researchonline.lshtm.ac.uk/id/eprint/9512

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