Birth size and survival in breast cancer patients from the Uppsala Birth Cohort Study.


Sovio, U; Jones, R; Dos Santos Silva, I; Koupil, I; (2013) Birth size and survival in breast cancer patients from the Uppsala Birth Cohort Study. Cancer causes & control. ISSN 0957-5243 DOI: https://doi.org/10.1007/s10552-013-0238-5

[img]
Preview
Text - Accepted Version
License:

Download (230kB) | Preview

Abstract

PURPOSE: Previous studies suggest that larger birth size is associated with a higher breast cancer incidence, but studies on birth measures and mortality in breast cancer cases are scarce. This study investigates survival of women after breast cancer diagnosis (n = 437) in the Uppsala Birth Cohort born in 1915-1929. METHODS: Cox regression was used to analyze mortality from any cause after a breast cancer diagnosis. Birth measures including gestational age (GA), birth weight (BW), BW for GA, birth length, and ponderal index (PI) were converted to standard deviation (SD) scores, and all analyses were adjusted for age and calendar time at diagnosis. Analyses were performed with and without adjustment for other birth measures, reproductive history, and adult socioeconomic position. RESULTS: In fully adjusted analyses, one SD increase in GA was associated with 17 % [95 % confidence interval (CI) 6-26 %] lower mortality and one SD increase in BW was associated with 29 % (7-56 %) higher mortality. PI showed a weaker trend in the same direction: hazard ratio = 1.16 (95 % CI 1.03-1.30). CONCLUSIONS: Our results bring in new evidence that both high GA and low BW predict a better survival in breast cancer cases. Further studies need to investigate mediation of these associations.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 23722348
Web of Science ID: 322879200002
URI: http://researchonline.lshtm.ac.uk/id/eprint/931384

Statistics


Download activity - last 12 months
Downloads since deposit
392Downloads
314Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item