Quinine levels revisited: the value of routine drug level monitoring for those on parenteral therapy


Flanagan, KL; Buckley-Sharp, M; Doherty, T; Whitty, CJM; (2006) Quinine levels revisited: the value of routine drug level monitoring for those on parenteral therapy. Acta tropica, 97 (2). pp. 233-237. ISSN 0001-706X DOI: https://doi.org/10.1016/j.actatropica.2005.11.006

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Abstract

Parenteral quinine is the most frequently used first line treatment for severe Plasmodium falciparum malaria in the developed world. Quinine is known to have a number of toxic side effects including cardiotoxicity, ototoxicity and ocular toxicity. Many therefore advocate routine monitoring of quinine levels for patients receiving parenteral therapy. This paper reviews current evidence on the usefulness of quinine level monitoring in the context of 73 adult patients with severe P. falciparum malaria managed by the Hospital for Tropical Diseases in London. Combining data from these patients with a comprehensive literature review, we conclude that routine quinine level monitoring in all patients receiving parenteral therapy is seldom appropriate.

Item Type: Article
Keywords: Animals, Antimalarials, Drug Monitoring, Humans, Infusions, Parenteral, Malaria, Falciparum, Plasmodium falciparum, Quinine, Animals, Antimalarials, administration & dosage, blood, Drug Monitoring, Humans, Infusions, Parenteral, Malaria, Falciparum, blood, drug therapy, Plasmodium falciparum, growth & development, Quinine, administration & dosage, blood
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 16387280
Web of Science ID: 235105000016
URI: http://researchonline.lshtm.ac.uk/id/eprint/9153

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