A case-control study of syphilis among men who have sex with men in New York City: association With HIV infection


Paz-Bailey, G; Meyers, A; Blank, S; Brown, J; Rubin, S; Braxton, J; Zaidi, A; Schafzin, J; Weigl, S; Markowitz, LE; (2004) A case-control study of syphilis among men who have sex with men in New York City: association With HIV infection. Sexually transmitted diseases, 31 (10). pp. 581-7. ISSN 0148-5717 DOI: https://doi.org/10.1097/01.olq.0000140009.28121.0f

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Abstract

OBJECTIVE: The objective of this study was to determine factors associated with syphilis among men who report sex with other men in New York City. DESIGN, SETTING AND STUDY SUBJECTS: We conducted a case-control study among 88 men who reported sex with men in the previous year, 18 to 55 years old and diagnosed with primary or secondary syphilis during 2001; and 176 control subjects frequently matched by age and type of health provider. RESULTS: HIV prevalence among syphilis cases was 48% compared with 15% among control subjects (P <0.001). Variables associated with syphilis in a multivariate model were HIV infection (odds ratio [OR], 7.3; 95% confidence interval [CI], 3.5-15.4), income >$30,000 per year (OR, 2.7; CI, 1.4-5.2), and barebacking (OR, 2.6; CI, 1.4-4.8). The median time since HIV diagnosis for HIV-positive was 6 years for cases and 7 years for control subjects (P = 0.70). Among HIV-infected participants, syphilis cases were more likely than control subjects to report being on antiretroviral therapy (69% vs. 44%, P = 0.05) and to report having undetectable viral load (58% vs. 24%, P = 0.02). CONCLUSION: HIV infection was strongly associated with syphilis in this study. High-risk behavior reported by both cases and control subjects indicates the potential for increased HIV transmission.

Item Type: Article
Keywords: Adolescent, Adult, Antiretroviral Therapy, Highly Active, Case-Control Studies, HIV Infections/epidemiology/etiology, *Homosexuality, Male, Humans, Male, Middle Aged, New York City/epidemiology, Prevalence, Questionnaires, Risk Factors, Risk-Taking, Syphilis/*epidemiology/*etiology, Viral Load, Adolescent, Adult, Antiretroviral Therapy, Highly Active, Case-Control Studies, HIV Infections, epidemiology, etiology, Homosexuality, Male, Humans, Male, Middle Aged, New York City, epidemiology, Prevalence, Questionnaires, Risk Factors, Risk-Taking, Syphilis, epidemiology, etiology, Viral Load
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 15388994
Web of Science ID: 224119900001
URI: http://researchonline.lshtm.ac.uk/id/eprint/8395

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