In the Era of Systematic Reviews, Does the Size of an Individual Trial Still Matter.


Guyatt, GH; Mills, EJ; Elbourne, D; (2008) In the Era of Systematic Reviews, Does the Size of an Individual Trial Still Matter. PLoS medicine, 5 (1). e4. ISSN 1549-1277 DOI: 10.1371/journal.pmed.0050004

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Abstract

Background to the debate: Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic reviews-and the fact that individual clinical trials rarely provide definitive answers to a clinical research question-some commentators question whether the sample size calculation for an individual trial still matters. Others point out that small trials can still be potentially misleading.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 18177203
Web of Science ID: 254928700002
URI: http://researchonline.lshtm.ac.uk/id/eprint/8311

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