The testing of saliva samples for HIV-1 antibodies: reliability in a non-clinic setting


Hunt, AJ; Connell, J; Christofinis, G; Parry, JV; Weatherburn, P; Hickson, FC; Coxon, APM; Davies, PM; McManus, TJ; Sutherland, S; (1994) The testing of saliva samples for HIV-1 antibodies: reliability in a non-clinic setting. Genito-Urinary Medicine, 69 (1). pp. 29-30. ISSN 0266-4348

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Abstract

Aims: To assess the reliability of saliva samples as a means of testing for HIV-antibodies outside clinic settings. Methods: Men taking part in a non-clinic longitudinal study of homosexually active men provided samples of saliva and blood. Sera was screened using a competitive ELISA (Wellcozyme) and positive sera were confirmed by an indirect ELISA (Abbott). Saliva samples were screened either using an IgG captive radioimmunoassay or an amplified ELISA. Results: A total of 534 paired saliva and blood sample were tested. Overall sensitivity was 96.2% and specificity was 100%. None of the saliva tests were falsely positive for HIV-1 antibodies. Conclusions: HIV-1 saliva tests can reliably be used in a non-clinic or field setting. However, if results are to be given to respondents, it is necessary to offer adequate counselling and consider the mechanisms for referral and follow-up for those that are found to be HIV-1 antibody positive.

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
Research Centre: Sigma Research
PubMed ID: 8444477
URI: http://researchonline.lshtm.ac.uk/id/eprint/812501

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