Lithothamnin A, the First Bastadin-like Metabolite from the Red Alga Lithothamnion fragilissimum.


Van Wyk, AW; Zuck, KM; McKee, TC; (2011) Lithothamnin A, the First Bastadin-like Metabolite from the Red Alga Lithothamnion fragilissimum. Journal of natural products. ISSN 0163-3864 DOI: https://doi.org/10.1021/np1006795

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Abstract

Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural features that distinguish it from other bastadins. These unique structural features include novel aromatic substitution patterns and the presence of a meta-meta linkage between aromatic rings, in addition to the meta-para linkage seen in the bastadins. Lithothamnin A is modestly cytotoxic in a panel of six human tumor cell lines.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 21488653
Web of Science ID: 291127900054
URI: http://researchonline.lshtm.ac.uk/id/eprint/795

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