High frequency of resistance to the drugs isoniazid and rifampicin among tuberculosis cases in the City of Cabo de Santo Agostinho, an urban area in Northeastern Brazil


Baliza, M; Bach, AH; de Queiroz, GL; Melo, IC; Carneiro, MM; de Albuquerque, M; Suffys, P; Rodrigues, L; Ximenes, R; Lucena-Silva, N; (2008) High frequency of resistance to the drugs isoniazid and rifampicin among tuberculosis cases in the City of Cabo de Santo Agostinho, an urban area in Northeastern Brazil. Revista da Sociedade Brasileira de Medicina Tropical, 41 (1). pp. 11-16. ISSN 0037-8682 DOI: https://doi.org/10.1590/S0037-86822008000100003

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Abstract

The objective of the present study was to investigate the frequency and risk factors for developing multidrug- resistant tuberculosis in Cabo de Santo Agostinho, PE. This was a prospective study conducted from 2000 to 2003, in which suspected cases were investigated using bacilloscopy and culturing. Out of 232 confirmed cases of tuberculosis, culturing and antibiotic susceptibility tests were performed on 174. Thirty- five of the 174 cultures showed resistance to all drugs. The frequencies of primary and acquired resistance to any drug were 14% and 50% respectively, while the frequencies of primary and acquired multidrug resistance were 8.3% and 40%. Previous tuberculosis treatment and abandonment of treatment were risk factors for drug resistance. The high levels of primary and acquired resistance to the combination of isoniazid and rifampicin contributed towards the difficulties in controlling tuberculosis transmission in the city.

Item Type: Article
Keywords: tuberculosis, drug resistance, multidrug resistance, risk factors, MYCOBACTERIUM-TUBERCULOSIS, PREVALENCE
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 18368264
Web of Science ID: 254387500003
URI: http://researchonline.lshtm.ac.uk/id/eprint/7551

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