Skin prick test reactivity to common allergens among women in Entebbe, Uganda


Mpairwe, H; Muhangi, L; Ndibazza, J; Tumusiime, J; Muwanga, M; Rodrigues, LC; Elliott, AM; (2008) Skin prick test reactivity to common allergens among women in Entebbe, Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102 (4). pp. 367-373. ISSN 0035-9203 DOI: 10.1016/j.trstmh.2008.01.017

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Abstract

The objectives of this study were to estimate the prevalence of atopic sensitization, and to identify common aeroallergens associated with atopic sensitization among women in Entebbe, Uganda, and to determine risk factors for atopic sensitization among those with and without a history of asthma or eczema. A case-control study was conducted within a trial of deworming in pregnancy, approximately 2 years after the intervention. Skin prick test reactivity was assessed among 20 women with a history of asthma, 25 with history of eczema and 95 controls. Overall prevalence of reactivity was estimated by adjusting for the prevalence of asthma in the whole cohort. Overall skin prick test prevalence was: any allergen 30.7%, Blomia tropicalis 10.9%, Dermatophagoides mix 16.8%, cockroach 15.8%. The prevalence of a positive skin prick test was significantly associated with a history of asthma (70% to any allergen vs. 32%, P= 0.002) but not with a history of eczema (44% vs. 36%, P= 0.49). Women with Mansonella perstans had significantly reduced odds for atopic sensitization (adjusted odds ratio 0.14, 95% CI 0.03-0.69); women with a history of asthma were less likely to have hookworm (adjusted odds ratio 0.24, 95% CI 0.07-0.81) but this association was weaker for women with a history of eczema. [Clinical Trial No. ISRCTN32849447] (c) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: worms, allergy, atopy, skin prick test, Mansonella perstans, Uganda, GABONESE SCHOOLCHILDREN, HELMINTH INFECTION, PREVALENCE, ATOPY, CHILDREN, ASTHMA, URBAN, SENSITIZATION, PREGNANCY, TRIAL
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 18321545
Web of Science ID: 255043500014
URI: http://researchonline.lshtm.ac.uk/id/eprint/7550

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