Concurrent gastro-intestinal nematode infection does not alter the development of experimental cerebral malaria.


de Souza, JB; Helmby, H; (2008) Concurrent gastro-intestinal nematode infection does not alter the development of experimental cerebral malaria. Microbes and infection / Institut Pasteur, 10 (8). pp. 916-21. ISSN 1286-4579 DOI: https://doi.org/10.1016/j.micinf.2008.04.015

[img]
Preview
Text - Published Version
License:

Download (602kB) | Preview

Abstract

Concurrent helminth infections have been suggested to be associated with protection against cerebral malaria in humans, a condition characterised by systemic inflammation. Here we show that a concurrent chronic gastro-intestinal nematode infection does not alter the course of murine cerebral malaria. Mice infected with Heligmosomoides polygyrus, and co-infected with Plasmodium berghei ANKA 14 days later, developed malaria parasitemia, weight loss and anemia, at the same rate as mice without nematode infection. Both groups developed cerebral malaria around the same time point. The data suggest that a chronic helminth infection does not affect the development of cerebral malaria in a murine model.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 18656411
Web of Science ID: 259421800010
URI: http://researchonline.lshtm.ac.uk/id/eprint/7402

Statistics


Download activity - last 12 months
Downloads since deposit
197Downloads
312Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item