Relationship between Levels of Inflammatory Cytokines in the Genital Tract and CD4(+) Cell Counts in Women with Acute HIV-1 Infection.


Bebell, LM; Passmore, JA; Williamson, C; Mlisana, K; Iriogbe, I; van Loggerenberg, F; Karim, QA; Karim, SA; (2008) Relationship between Levels of Inflammatory Cytokines in the Genital Tract and CD4(+) Cell Counts in Women with Acute HIV-1 Infection. The Journal of infectious diseases, 198 (5). pp. 710-714. ISSN 0022-1899 DOI: https://doi.org/10.1086/590503

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Abstract

Inflammatory responses at mucosal surfaces after human immunodeficiency virus type 1 (HIV-1) transmission may influence disease outcome. We evaluated levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, IL-8, IL-10, and IL-12 in genital tract and plasma specimens from 44 women with acute HIV infection and 29 HIV-negative control women (13 of whom were women in the acute HIV infection cohort who had preinfection samples available for analysis). Women with acute HIV infection had significantly elevated levels of IL-6, IL-10, and IL-12 in genital tract specimens and elevated levels of IL-1beta, IL-8, and IL-10 in plasma specimens, compared with HIV-negative control women. Levels of IL-1beta, IL-6, and IL-8 in cervicovaginal specimens from women with acute HIV infection showed a significant inverse correlation with systemic CD4(+) cell counts, suggesting that mucosal inflammation is associated with low CD4(+) cell counts during acute HIV infection.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 18643751
Web of Science ID: 258363700013
URI: http://researchonline.lshtm.ac.uk/id/eprint/7233

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