The case for hypervirulence through gene deletion in Mycobacterium tuberculosis


Ten Bokum, AMC; Movahedzadeh, F; Frita, R; Bancroft, GJ; Stoker, NG; (2008) The case for hypervirulence through gene deletion in Mycobacterium tuberculosis. Trends in microbiology, 16 (9). pp. 436-441. ISSN 0966-842X DOI: https://doi.org/10.1016/j.tim.2008.06.003

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Abstract

Deletion of genes in a pathogen is commonly associated with a reduction in its ability to cause disease. However, some rare cases have been described in the literature whereby deletion of a gene results in an increase in virulence. Recently, there have been several reports of hypervirulence resulting from gene deletion in Mycobacterium tuberculosis. Here, we explore this phenomenon in the context of the interaction between the pathogen and the host response.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: TB Centre
Web of Science ID: 259751800006
URI: http://researchonline.lshtm.ac.uk/id/eprint/6578

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