Recombinant Salmonella vaccines for biodefence


Atkins, HS; Morton, M; Griffin, KF; Stokes, MGM; Nataro, JP; Titball, RW; (2006) Recombinant Salmonella vaccines for biodefence. Vaccine, 24 (15). pp. 2710-2717. ISSN 0264-410X DOI: 10.1016/j.vaccine.2005.12.046

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Abstract

There is a requirement for vaccines to protect against pathogens that may be misused for bioterrorism or biowarfare purposes. In particular, biodefence vaccines are required that may be used for safe and easy immunisation of populations and that can rapidly induce mucosal immunity to provide protection at the lung surface against a range of airborne agents. To address this need, recombinant Salmonella vaccines are being developed. In this review, the technologies used, considerations needed, progress made, and future prospects for developing multivalent Salmonella-based vaccines for biodefence are discussed. Crown Copyright (c) 2006 Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Salmonella vaccine, attenuated Salmonella, biodefence, ENTERICA SEROVAR TYPHI, IMMUNODEFICIENCY-VIRUS TYPE-1, LIVE ATTENUATED, SALMONELLA, GLUTATHIONE-S-TRANSFERASE, EXPRESSING FRAGMENT C, III, SECRETION SYSTEM, ESCHERICHIA-COLI, ANTIBODY-RESPONSES, ORAL, IMMUNIZATION, FOREIGN ANTIGENS, Biological Warfare, Bioterrorism, Humans, Salmonella, genetics, immunology, Salmonella Vaccines, genetics, immunology, Vaccines, Synthetic, genetics, immunology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Vaccine Centre
PubMed ID: 16434131
Web of Science ID: 236931700003
URI: http://researchonline.lshtm.ac.uk/id/eprint/6531

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