Does IFN-gamma play a role on the pathogenesis of non-atopic asthma in Latin America children?


Figueiredo, CA; Rodrigues, LC; Alcantara-Neves, NM; Cooper, PJ; Amorim, LD; Silva, NB; Cruz, AA; Barreto, ML; (2012) Does IFN-gamma play a role on the pathogenesis of non-atopic asthma in Latin America children? Allergy, asthma, and clinical immunology, 8 (1). p. 18. ISSN 1710-1484 DOI: https://doi.org/10.1186/1710-1492-8-18

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Abstract

: ABSTRACT: In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-gamma) and Th2 (IL-5 and IL-13) cytokines in Dermatophagoides pteronyssinus stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-gamma and elevated monocytes in blood. IFN-gamma and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 23253516
URI: http://researchonline.lshtm.ac.uk/id/eprint/588945

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