Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions?


Bousema, T; Churcher, TS; Morlais, I; Dinglasan, RR; (2012) Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions? Trends in parasitology. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2012.11.004

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Abstract

: A recent meta-analysis of mosquito feeding assays to determine the Plasmodium falciparum transmission potential of naturally infected gametocyte carriers highlighted considerable variation in transmission efficiency between assay methodologies and between laboratories. This begs the question as to whether mosquito feeding assays should be used for the evaluation of transmission-reducing interventions in the field and whether these field-based mosquito assays are currently standardized sufficiently to enable accurate evaluations. Here, we address biological and methodological reasons for the observed variations, discuss whether these preclude the use of field-based mosquito feeding assays in field evaluations of transmission-blocking interventions, and propose how we can maximize the precision of estimates. Altogether, we underscore the significant advantages of field-based mosquito feeding assays in basic malaria research and field trials.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 23273727
Web of Science ID: 315180200001
URI: http://researchonline.lshtm.ac.uk/id/eprint/586556

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