Male circumcision and penile cancer: a systematic review and meta-analysis.


Larke, NL; Thomas, SL; dos Santos Silva, I; Weiss, HA; (2011) Male circumcision and penile cancer: a systematic review and meta-analysis. Cancer causes & control, 22 (8). pp. 1097-110. ISSN 0957-5243 DOI: https://doi.org/10.1007/s10552-011-9785-9

[img]
Preview
Text - Published Version
License:

Download (480kB) | Preview

Abstract

OBJECTIVE: We systematically reviewed the evidence of an association between male circumcision and penile cancer.<br/> METHODS: Databases were searched using keywords and text terms for the epidemiology of penile cancer. Random effects meta-analyses were used to calculate summary odds ratios (ORs) and 95% confidence intervals (CI).<br/> RESULTS: We identified eight papers which evaluated the association of circumcision with penile cancer, of which seven were case-control studies. There was a strong protective effect of childhood/adolescent circumcision on invasive penile cancer (OR = 0.33; 95% CI 0.13-0.83; 3 studies). In two studies, the protective effect of childhood/adolescent circumcision on invasive cancer no longer persisted when analyses were restricted to boys with no history of phimosis. In contrast, there was some evidence that circumcision in adulthood was associated with an increased risk of invasive penile cancer (summary OR = 2.71; 95% CI 0.93-7.94; 3 studies). There was little evidence for an association of penile intra-epithelial neoplasia and in situ penile cancer with circumcision performed at any age.<br/> CONCLUSIONS: Men circumcised in childhood/adolescence are at substantially reduced risk of invasive penile cancer, and this effect could be mediated partly through an effect on phimosis. Expansion of circumcision services in sub-Saharan Africa as an HIV prevention strategy may additionally reduce penile cancer risk.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Tropical Epidemiology Group
PubMed ID: 21695385
Web of Science ID: 292928300003
URI: http://researchonline.lshtm.ac.uk/id/eprint/580

Statistics


Download activity - last 12 months
Downloads since deposit
281Downloads
362Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item