Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy.


Lalor, MK; Ben-Smith, A; Gorak-Stolinska, P; Weir, RE; Floyd, S; Blitz, R; Mvula, H; Newport, MJ; Branson, K; McGrath, N; Crampin, AC; Fine, PE; Dockrell, HM; (2009) Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy. The Journal of infectious diseases, 199 (6). pp. 795-800. ISSN 0022-1899 DOI: 10.1086/597069

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Abstract

: Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)-gamma response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents. We hypothesized that Mtb PPD-induced IFN-gamma after BCG vaccination would be similar in infants from these 2 countries. Infants were vaccinated with BCG during the first 3-13 weeks of life. Three months after BCG vaccination, 51 (100%) of 51 UK infants had an IFN-gamma response to Mtb PPD, compared to 41 (53%) of 78 of Malawian infants, in whom responses varied according to their season of birth. We conclude that population differences in immune responses after BCG vaccination are observed among infants, as well as among young adults.<br/>

Item Type: Article
Faculty and Department: Academic Services & Administration > Academic Administration
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
TB Centre
Vaccine Centre
MEIRU
Population Studies Group
Tropical Epidemiology Group
PubMed ID: 19434928
Web of Science ID: 263677900005
URI: http://researchonline.lshtm.ac.uk/id/eprint/5427

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