Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.


Ahmed, S; Thomas, G; Ghoussaini, M; Healey, CS; Humphreys, MK; Platte, R; Morrison, J; Maranian, M; Pooley, KA; Luben, R; Eccles, D; Evans, DG; Fletcher, O; Johnson, N; dos Santos Silva, I; Peto, J; Stratton, MR; Rahman, N; Jacobs, K; Prentice, R; Anderson, GL; Rajkovic, A; Curb, JD; Ziegler, RG; Berg, CD; Buys, SS; McCarty, CA; Feigelson, HS; Calle, EE; Thun, MJ; Diver, WR; Bojesen, S; Nordestgaard, BG; Flyger, H; Dörk, T; Schürmann, P; Hillemanns, P; Karstens, JH; Bogdanova, NV; Antonenkova, NN; Zalutsky, IV; Bermisheva, M; Fedorova, S; Khusnutdinova, E; SEARCH, ; Kang, D; Yoo, KY; Noh, DY; Ahn, SH; Devilee, P; van Asperen, CJ; Tollenaar, RA; Seynaeve, C; Garcia-Closas, M; Lissowska, J; Brinton, L; Peplonska, B; Nevanlinna, H; Heikkinen, T; Aittomäki, K; Blomqvist, C; Hopper, JL; Southey, MC; Smith, L; Spurdle, AB; Schmidt, MK; Broeks, A; van Hien, RR; Cornelissen, S; Milne, RL; Ribas, G; González-Neira, A; Benitez, J; Schmutzler, RK; Burwinkel, B; Bartram, CR; Meindl, A; Brauch, H; Justenhoven, C; Hamann, U; GENICA Consortium, ; Chang-Claude, J; Hein, R; Wang-Gohrke, S; Lindblom, A; Margolin, S; Mannermaa, A; Kosma, VM; Kataja, V; Olson, JE; Wang, X; Fredericksen, Z; Giles, GG; Severi, G; Baglietto, L; English, DR; Hankinson, SE; Cox, DG; Kraft, P; Vatten, LJ; Hveem, K; Kumle, M; Sigurdson, A; Doody, M; Bhatti, P; Alexander, BH; Hooning, MJ; van den Ouweland, AM; Oldenburg, RA; Schutte, M; Hall, P; Czene, K; Liu, J; Li, Y; Cox, A; Elliott, G; Brock, I; Reed, MW; Shen, CY; Yu, JC; Hsu, GC; Chen, ST; Anton-Culver, H; Ziogas, A; Andrulis, IL; Knight, JA; kConFab, ; Australian Ovarian Cancer Study Group, ; Beesley, J; Goode, EL; Couch, F; Chenevix-Trench, G; Hoover, RN; Ponder, BA; Hunter, DJ; Pharoah, PD; Dunning, AM; Chanock, SJ; Easton, DF; (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nature genetics, 41 (5). pp. 585-90. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.354

Full text not available from this repository.

Abstract

Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 19330027
Web of Science ID: 265575600020
URI: http://researchonline.lshtm.ac.uk/id/eprint/5409

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
314Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item