Evaluation of commercially available anti-dengue virus immunoglobulin M tests


Hunsperger, EA; Yoksan, S; Buchy, P; Nguyen, VC; Sekaran, SD; Enria, DA; Pelegrino, JL; Vazquez, S; Artsob, H; Drebot, M; Gubler, DJ; Halstead, SB; Guzman, MG; Margolis, HS; Nathanson, CM; Rizzo Lic, NR; Bessoff, KE; Kliks, S; Peeling, RW; (2009) Evaluation of commercially available anti-dengue virus immunoglobulin M tests. Emerging infectious diseases, 15 (3). pp. 436-40. ISSN 1080-6040 DOI: https://doi.org/10.3201/eid1503.080923

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Abstract

Anti-dengue virus immunoglobulin M kits were evaluated. Test sensitivities were 21%-99% and specificities were 77%-98% compared with reference ELISAs. False-positive results were found for patients with malaria or past dengue infections. Three ELISAs showing strong agreement with reference ELISAs will be included in the World Health Organization Bulk Procurement Scheme.

Item Type: Article
Keywords: Antibodies, Viral/*blood, Dengue/*diagnosis/virology, Dengue Virus/*immunology, Enzyme-Linked Immunosorbent Assay, False Positive Reactions, Humans, Immunoglobulin M/*blood, *Reagent Kits, Diagnostic, Reproducibility of Results, Sensitivity and Specificity, Antibodies, Viral, blood, Dengue, diagnosis, virology, Dengue Virus, immunology, Enzyme-Linked Immunosorbent Assay, False Positive Reactions, Humans, Immunoglobulin M, blood, Reagent Kits, Diagnostic, Reproducibility of Results, Sensitivity and Specificity
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 19239758
Web of Science ID: 263759400011
URI: http://researchonline.lshtm.ac.uk/id/eprint/4713

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