da Hora, Laís Cristine Delgado; Muniz, Lilian Ferreira; Venâncio, Leonardo Gleygson Angelo; Advíncula, Karina Paes; da Silva, Jéssica Dayane; de Albuquerque Britto, Diana Babini Lapa; de Barros Miranda Filho, Demócrito; Brickley, Elizabeth B; de Alencar Ximenes, Ricardo Arraes; da Silva Caldas Neto, Silvio; +1 more... de Carvalho Leal, Mariana; (2022) Cortical Auditory Evoked Potentials in Children with Prenatal Exposure to Zika Virus. Viruses, 14 (9). p. 1923. ISSN 1999-4915 DOI: https://doi.org/10.3390/v14091923
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Abstract
Prenatal exposure to ZIKV can cause neurologic and auditory damage. The electrophysiological responses obtained by Cortical Auditory Evoked Potentials (CAEP) may provide an objective method to investigate the function of cortical auditory pathways in children exposed to ZIKV. This case series analyzed the findings of CAEP in prenatal-period ZIKV-exposed children with and without microcephaly. The CAEP was performed in a total of 24 children. Five magnetic resonance imaging (MRI) images of the inner ear and brain of microcephalic children were analyzed and compared with CAEP measurements. Ventriculomegaly (80%), cortical/subcortical calcification (80%), and brain reduction (60%) were the most common alterations in the MRI. The P1-N1-P2 complex of the CAEP was observed in all children evaluated. The peak N2 was absent in two children. In the comparison of the CAEP measurements between the groups, children with microcephaly presented a higher amplitude of P2 (p = 0.017), which may reflect immaturity of the auditory pathways. Microcephalic and normocephalic children with prenatal exposure to ZIKV presented with the mandatory components of the CAEPs, regardless of changes in the CNS, suggesting that this population has, to some extent, the cortical ability to process sound stimuli preserved.
Item Type | Article |
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Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) |
Research Centre | Centre for Maternal, Reproductive and Child Health (MARCH) |
PubMed ID | 36146729 |
Elements ID | 183050 |
Official URL | http://dx.doi.org/10.3390/v14091923 |
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