Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis.

Walker, NF; Karim, F; Moosa, MYS; Moodley, S; Mazibuko, M; Khan, K; Sterling, TR; van der Heijden, YF; Grant, AD; Elkington, PT; +2 more... Pym, A; Leslie, A; (2022) Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis. The Journal of Infectious Diseases, 226 (5). pp. 928-932. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jiac160

Abstract

Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture-positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542-9188] vs 698 [218-4060] pg/mL, respectively; P = .004) and after (3650 [1214-3888] vs 720 [551-1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre	TB Centre
PubMed ID	35510939
Elements ID	177157