Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings.
Muehlenbachs, Atis;
de la Rosa Vázquez, Olimpia;
Bausch, Daniel G;
Schafer, Ilana J;
Paddock, Christopher D;
Nyakio, Jean Paul;
Lame, Papys;
Bergeron, Eric;
McCollum, Andrea M;
Goldsmith, Cynthia S;
+9 more...Bollweg, Brigid C;
Prieto, Miriam Alía;
Lushima, Robert Shongo;
Ilunga, Benoit Kebela;
Nichol, Stuart T;
Shieh, Wun-Ju;
Ströher, Ute;
Rollin, Pierre E;
Zaki, Sherif R;
(2017)
Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings.
The Journal of infectious diseases, 215 (1).
pp. 64-69.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jiw206
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Here we describe clinicopathologic features of Ebola virus disease in pregnancy. One woman infected with Sudan virus in Gulu, Uganda, in 2000 had a stillbirth and survived, and another woman infected with Bundibugyo virus had a live birth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemical analysis, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malarial parasite pigment-laden macrophages. These data suggest that trophoblast infection may be a mechanism of transplacental ebolavirus transmission.