Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells.


Nabatanzi, R; Cose, S; Joloba, M; Jones, SR; Nakanjako, D; (2018) Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells. AIDS research and therapy, 15 (1). p. 7. ISSN 1742-6405 DOI: https://doi.org/10.1186/s12981-018-0194-y

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Abstract

HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although antiretroviral therapy (ART) restores CD4 T-cell counts, the persistent aberrant activation of monocytes, NK and ILCs observed likely contributes to the incomplete recovery of T-cell effector functions. A better understanding of the effects of HIV infection and ART on the phenotype and function of circulating monocytes, NK, and ILCs is required to guide development of novel therapeutic interventions to optimize immune recovery.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 29544508
URI: http://researchonline.lshtm.ac.uk/id/eprint/4647082

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