Polymorphisms of interleukin-10 and tumour necrosis factor-alpha genes are associated with newly diagnosed and recurrent pulmonary tuberculosis.


Oh, JH; Yang, CS; Noh, YK; Kweon, YM; Jung, SS; Son, JW; Kong, SJ; Yoon, JU; Lee, JS; Kim, HJ; Park, JK; Jo, EK; Song, CH; (2007) Polymorphisms of interleukin-10 and tumour necrosis factor-alpha genes are associated with newly diagnosed and recurrent pulmonary tuberculosis. Respirology (Carlton, Vic), 12 (4). pp. 594-8. ISSN 1323-7799 DOI: 10.1111/j.1440-1843.2007.01108.x

Full text not available from this repository.

Abstract

BACKGROUND AND OBJECTIVES: The genetic determinants for developing TB or having recurrent TB are unknown. The present study investigated the relationship between susceptibility to tuberculosis and human tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 genes (IL-10). METHODS: A case-control study was conducted using two groups of cases--newly diagnosed TB (N-TB) and recurrent TB (R-TB)--and a control group. RESULTS: One hundred and seventeen healthy controls, 80 newly diagnosed TB patients and 65 patients with recurrent TB were enrolled. There was no significant difference in the TNF-alpha-308 G/A genotype between the TB patient groups and the controls. The IL-10 -1082A alleles were markedly over-represented among the TB patient groups compared with the control subjects, however, there was no significant difference in the IL-10 genotype frequency between the N-TB and R-TB patient groups. CONCLUSION: The -1082A allele of the IL-10 gene may be important in determining susceptibility to TB, however, the -308 allele of the TNF-alpha gene does not affect differential TB susceptibility.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 17587429
Web of Science ID: 247440300020
URI: http://researchonline.lshtm.ac.uk/id/eprint/4598

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
257Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item