Epidemiological studies of the non-specific effects of vaccines: II - methodological issues in the design and analysis of cohort studies


Farrington, CP; Firth, MJ; Moulton, LH; Ravn, H; Andersen, PK; Evans, S; on behalf of the Working Group on Non-specific Effects of Vaccin, ; (2009) Epidemiological studies of the non-specific effects of vaccines: II - methodological issues in the design and analysis of cohort studies. Tropical medicine & international health , 14 (9). pp. 977-985. ISSN 1360-2276 DOI: 10.1111/j.1365-3156.2009.02302.x

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Abstract

We review sources of bias which can affect non-randomized cohort studies of non-specific effects of vaccines on child mortality. Using examples from the literature on non-specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.

Item Type: Article
Keywords: vaccines, mortality, non-specific effects, methodology, child survival, routine immunizations, propensity score, guinea-bissau, vaccination, mortality, situation, Bias (Epidemiology), Child, Preschool, Cohort Studies, Forms and Records Control, Humans, Infant, Medical Records, Vaccination, mortality, Vaccines, adverse effects
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Vaccine Centre
PubMed ID: 19531116
Web of Science ID: 269263800002
URI: http://researchonline.lshtm.ac.uk/id/eprint/4565

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