Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease.
Wolf, N;
Quaranta, M;
Prescott, NJ;
Allen, M;
Smith, R;
Burden, AD;
Worthington, J;
Griffiths, CEM;
Mathew, CG;
Barker, JN;
+2 more...Capon, F;
Trembath, RC;
(2008)
Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease.
J Med Genet, 45 (2).
pp. 114-116.
ISSN 0022-2593
DOI: https://doi.org/10.1136/jmg.2007.053595
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BACKGROUND: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD). OBJECTIVE AND METHODS: To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case-control dataset. RESULTS: The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes. CONCLUSIONS: These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders.
