Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection.


Hamlyn, E; Hickling, S; Porter, K; Frater, J; Phillips, R; Robinson, M; Mackie, NE; Kaye, S; McClure, M; Fidler, S; SPARTAC Investigators, [inc Ewings, FM; ], ; (2012) Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection. AIDS (London, England), 26 (7). pp. 887-90. ISSN 0269-9370 DOI: https://doi.org/10.1097/QAD.0b013e328351e721

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Abstract

CXCR4-tropic (X4) HIV-1 variants are associated with faster disease progression compared with CCR5-tropic variants; however, the mechanism for this is unclear. We measured T-cell activation in 120 individuals with primary HIV-1 infection. X4-utilizing variants, determined genotypically, were present in 8.3% of the participants and were associated with higher levels of CD4 T-cell activation, even after adjusting for other prognostic factors. Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Tropical Epidemiology Group
PubMed ID: 22313951
Web of Science ID: 302813000015
URI: http://researchonline.lshtm.ac.uk/id/eprint/427487

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