Challenges in the Design and Interpretation of Noninferiority Trials: Insights From Recent Stent Trials.


Macaya, F; Ryan, N; Salinas, P; Pocock, SJ; (2017) Challenges in the Design and Interpretation of Noninferiority Trials: Insights From Recent Stent Trials. Journal of the American College of Cardiology, 70 (7). pp. 894-903. ISSN 0735-1097 DOI: https://doi.org/10.1016/j.jacc.2017.06.039

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Abstract

: The noninferiority design is used extensively in current clinical research, but its complex features may hamper the appropriate interpretation of such trials. Thus, understanding the pillars of noninferiority design is indispensable. The authors discuss fundamental concepts regarding the design and interpretation of noninferiority trials and then explore some common methodological criticism by analyzing a sample of contemporary coronary stent trials. Finally, the authors give an overall perspective to enhance the design and conduct of future trials.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 28797360
Web of Science ID: 407028500012
URI: http://researchonline.lshtm.ac.uk/id/eprint/4224342

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