BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control.


Merle, CS; Cunha, SS; Rodrigues, LC; (2010) BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control. Expert review of vaccines, 9 (2). pp. 209-22. ISSN 1476-0584 DOI: 10.1586/erv.09.161

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Abstract

The bacillus Calmette-Gu?rin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the heterogeneity of the results. We conducted a meta-analysis of published data including recently published studies (up to June 2009) to determine the efficacy of BCG protection on leprosy and to investigate whether age at vaccination, clinical form, number of doses, type of study, the latitude of study area and year of publication influence the degree of efficacy and explain the variation. In the light of the results, we argue for more emphasis on the role of BCG vaccination in leprosy control and research.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Neglected Tropical Diseases Network
Vaccine Centre
TB Centre
Tropical Epidemiology Group
PubMed ID: 20109030
Web of Science ID: 274499300013
URI: http://researchonline.lshtm.ac.uk/id/eprint/4190

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