The distribution of Plasmodium falciparum infection durations.


Bretscher, MT; Maire, N; Chitnis, N; Felger, I; Owusu-Agyei, S; Smith, T; (2011) The distribution of Plasmodium falciparum infection durations. Epidemics, 3 (2). pp. 109-18. ISSN 1755-4365 DOI: https://doi.org/10.1016/j.epidem.2011.03.002

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Abstract

The duration of untreated Plasmodium falciparum infections in naturally exposed human populations is of interest for rational planning of malaria control interventions as it is related to the duration of infectivity. The extent of variability in duration is relevant where transmission is seasonal, and for the planning of elimination efforts. Methods for measuring these quantities from genotyping data have been restricted to exponential models of infection survival, as implied by constant clearance rates. Such models have greatly improved the understanding of infection dynamics on a population level but likely misrepresent the within-host dynamics of many pathogens. Conversely, the statistical properties of the distribution of infection durations, and how these are affected by exposure, should contain information on within-host dynamics.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 21624782
Web of Science ID: 300706300007
URI: http://researchonline.lshtm.ac.uk/id/eprint/393

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