Effect of early intervention on 5-year outcome in non-affective psychosis

Gafoor, R; Nitsch, D; McCrone, P; Craig, TKJ; Garety, PA; Power, P; McGuire, P; (2010) Effect of early intervention on 5-year outcome in non-affective psychosis. The British journal of psychiatry, 196 (5). pp. 372-376. ISSN 0007-1250 DOI: https://doi.org/10.1192/bjp.bp.109.066050

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Background Early specialised care may improve short-term outcome in first-episode non-affective psychosis, but it is unclear if these benefits endure. Aims To assess the long-term effect of early intervention in psychosis. Method Individuals with first-episode psychosis were randomised to specialised care or care as usual (trial number: ISRCTN73679874). Outcome after 5 years was assessed by case-note review. Results There were no significant differences in the admission rate (coefficient 0.096, 95% CI -0.550 to 0.742, P=0.770) or the mean number of bed days (coefficient 6.344, 95% CI -46 to 58.7, P= 0.810). Conclusions These findings that specialist intervention did not markedly improved outcome at 5 years accord with those from a larger OPUS study. The sample size of this study was small and these results should be generalised with caution. More research is needed.

Item Type: Article
Keywords: cognitively-oriented psychotherapy, randomized multicenter trial, standard treatment, follow-up, illness, disorders, community, prisons, cope
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 20435962
Web of Science ID: 277422200008
URI: http://researchonline.lshtm.ac.uk/id/eprint/3706


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