Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?


Titball, RW; Burtnick, MN; Bancroft, GJ; Brett, P; (2017) Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials? Vaccine. ISSN 0264-410X DOI: 10.1016/j.vaccine.2017.03.022

Full text not available from this repository.

Abstract

B. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and animals. The closely related bacterium B. mallei, which cases glanders, is considered to be a clonal derivative of B. pseudomallei. Both B. pseudomallei and B. mallei were evaluated by the United States and the former USSR as potential bioweapons. Much of the effort to devise biodefence vaccines in the past decade has been directed towards the identification and formulation of sub-unit vaccines which could protect against both melioidosis and glanders. A wide range of proteins and polysaccharides have been identified which protective immunity in mice. In this review we highlight the significant progress that has been made in developing glycoconjugates as sub-unit vaccines. We also consider some of the important the criteria for licensing, including the suitability of the "animal rule" for assessing vaccine efficacy, the protection required from a vaccine and the how correlates of protection will be identified. Vaccines developed for biodefence purposes could also be used in regions of the world where naturally occurring disease is endemic.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 28336210
URI: http://researchonline.lshtm.ac.uk/id/eprint/3682725

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
23Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item