Effect of Ivermectin on Anopheles gambiae Mosquitoes Fed on Humans: The Potential of Oral Insecticides in Malaria Control.


Chaccour, C; Lines, J; Whitty, CJ; (2010) Effect of Ivermectin on Anopheles gambiae Mosquitoes Fed on Humans: The Potential of Oral Insecticides in Malaria Control. The Journal of infectious diseases, 202 (1). pp. 113-6. ISSN 0022-1899 DOI: https://doi.org/10.1086/653208

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Abstract

: Anopheles gambiae mosquitoes were fed on 25 volunteers randomized to receive ivermectin or nothing. In mosquitoes feeding on volunteers given ivermectin the previous day, mean survival was 2.3 days, compared with 5.5 days in the control group (P < .001, by log-lank test). Mosquito mortality was 73%, 84%, and 89% on days 2, 3, and 4 in the ivermectin group. In mosquitoes fed 14 days after treatment, no difference was found between groups. Ivermectin is safe and has significant short-term insecticidal properties. A systemic insecticide taken by humans could help to control malaria in areas where mosquitoes are exophagic or exophilic and drug resistance is an urgent threat.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Malaria Centre
PubMed ID: 20482251
Web of Science ID: 278322300014
URI: http://researchonline.lshtm.ac.uk/id/eprint/3658

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