Amodiaquine resistance in Plasmodium falciparum malaria is associated with the pfcrt 72-76 SVMNT allele in Afghanistan.


Beshir, K; Sutherland, CJ; Merinopoulos, I; Durrani, N; Leslie, T; Rowland, M; Hallett, RL; (2010) Amodiaquine resistance in Plasmodium falciparum malaria is associated with the pfcrt 72-76 SVMNT allele in Afghanistan. Antimicrobial agents and chemotherapy, 54 (9). pp. 3714-6. ISSN 0066-4804 DOI: 10.1128/AAC.00358-10

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Abstract

: Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa. To examine the importance of these mutations in amodiaquine-treated Asian parasites, we determined pre- and posttreatment genotypes for amodiaquine treatment failures from a clinical trial in Afghanistan. The pfcrt codon 72 to 76 haplotype SVMNT was present in all samples tested, both before and after treatment. Amodiaquine did not clearly select for any pfmdr1 genotype, but a novel mutation, pfmdr1 N86F, was detected in four samples. We provide in vivo data to support the in vitro correlation between pfcrt SVMNT and increased resistance to the metabolite of amodiaquine.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
Health in Humanitarian Crises Centre
PubMed ID: 20547800
Web of Science ID: 281005900027
URI: http://researchonline.lshtm.ac.uk/id/eprint/3445

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