Modelling and analysis of the effects of malnutrition in the spread of cholera


Hove-Musekwa, SD; Nyabadza, F; Chiyaka, C; Das, P; Tripathi, A; Mukandavire, Z; (2011) Modelling and analysis of the effects of malnutrition in the spread of cholera. Mathematical and computer modelling, 53 (9-10). pp. 1583-1595. ISSN 0895-7177

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Abstract

Although cholera has existed for ages, it has continued to plague many parts of the world. In this study, a deterministic model for cholera in a community is presented and rigorously analysed in order to determine the effects of malnutrition in the spread of the disease. The important mathematical features of the cholera model are thoroughly investigated. The epidemic threshold known as the basic reproductive number and equilibria for the model are determined, and stabilities are investigated. The disease-free equilibrium is shown to be globally asymptotically stable. Local stability of the endemic equilibrium is determined using centre manifold theory and conditions for its global stability are derived using a suitable Lyapunov function. Numerical simulations suggest that an increase in susceptibility to cholera due to malnutrition results in an increase in the number of cholera infected individuals in a community. The results suggest that nutritional issues should be addressed in impoverished communities affected by cholera in order to reduce the burden of the disease. (C) 2010 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Cholera model, Malnutrition, Susceptibility, Reproduction number, Equilibria, Stability, differential susceptibility, disease transmission, infectious-diseases, epidemic models, vibrio-cholerae, dynamics, bacteriophage, hiv
Faculty and Department: Faculty of Public Health and Policy > Dept of Global Health and Development
Research Centre: Social and Mathematical Epidemiology (SaME)
SaME Modelling & Economics
Web of Science ID: 287729700001
URI: http://researchonline.lshtm.ac.uk/id/eprint/333669

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