Estimating Plasmodium falciparum Transmission Rates in Low-Endemic Settings Using a Combination of Community Prevalence and Health Facility Data.


Yukich, J; Briët, O; Bretscher, MT; Bennett, A; Lemma, S; Berhane, Y; Eisele, TP; Keating, J; Smith, T; (2012) Estimating Plasmodium falciparum Transmission Rates in Low-Endemic Settings Using a Combination of Community Prevalence and Health Facility Data. PLoS One, 7 (8). e42861. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0042861

[img]
Preview
Text - Published Version
License:

Download (340kB) | Preview

Abstract

As some malaria control programs shift focus from disease control to transmission reduction, there is a need for transmission data to monitor progress. At lower levels of transmission, it becomes increasingly more difficult to measure precisely, for example through entomological studies. Many programs conduct regular cross sectional parasite prevalence surveys, and have access to malaria treatment data routinely collected by ministries of health, often in health management information systems. However, by themselves, these data are poor measures of transmission. In this paper, we propose an approach for combining annual parasite incidence and treatment data with cross-sectional parasite prevalence and treatment seeking survey data to estimate the incidence of new infections in the human population, also known as the force of infection. The approach is based on extension of a reversible catalytic model. The accuracy of the estimates from this model appears to be highly dependent on levels of detectability and treatment in the community, indicating the importance of information on private sector treatment seeking and access to effective and appropriate treatment.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 22936995
Web of Science ID: 308286300027
URI: http://researchonline.lshtm.ac.uk/id/eprint/333629

Statistics


Download activity - last 12 months
Downloads since deposit
199Downloads
274Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item