The dissemination of multidrug-resistant Enterobacter cloacae throughout the UK and Ireland.


Moradigaravand, D; Reuter, S; Martin, V; Peacock, SJ; Parkhill, J; (2016) The dissemination of multidrug-resistant Enterobacter cloacae throughout the UK and Ireland. Nat Microbiol, 1. p. 16173. ISSN 2058-5276 DOI: 10.1038/nmicrobiol.2016.173

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Abstract

: Enterobacter cloacae is a clinically important Gram-negative member of the Enterobacteriaceae, which has increasingly been recognized as a major pathogen in nosocomial infections. Despite this, knowledge about the population structure and the distribution of virulence factors and antibiotic-resistance determinants of this species is scarce. In this study, we analysed a systematic collection of multidrug-resistant E. cloacae isolated between 2001 and 2011 from bloodstream infections across hospitals in the UK and Ireland. We found that the population is characterized by the presence of multiple clones formed at widely different time periods in the past. The clones exhibit a high degree of geographical heterogeneity, which indicates extensive dissemination of these E. cloacae clones across the UK and Ireland. These findings suggest that a diverse, community-based, commensal population underlies multidrug-resistant E. cloacae infections within hospitals.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 27669519
Web of Science ID: 389140200006
URI: http://researchonline.lshtm.ac.uk/id/eprint/2933140

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