In vitro and in vivo studies of the trypanocidal activity of four terpenoid derivatives against Trypanosoma cruzi.


Ramírez-Macías, I; Marín, C; Chahboun, R; Messouri, I; Olmo, F; Rosales, MJ; Gutierrez-Sánchez, R; Alvarez-Manzaneda, E; Sánchez-Moreno, M; (2012) In vitro and in vivo studies of the trypanocidal activity of four terpenoid derivatives against Trypanosoma cruzi. The American journal of tropical medicine and hygiene, 87 (3). pp. 481-8. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.2012.11-0471

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Abstract

Four terpenoid derivatives were examined for their activity against Trypanosoma cruzi. Our results show that two compounds were very active in vitro against both extra- and intracellular forms. These compounds, non-toxic for the host cells, are more effective than the reference drug benznidazole. The capacity to infect cells was negatively affected and the number of amastigotes and trypomastigotes was reduced. A wide range of ultrastructural alterations was found in the epimastigote forms treated with these compounds. Some metabolic changes occurred presumably at the level of succinate and acetate production, perhaps caused by the disturbance of the enzymes involved in sugar metabolism inside the mitochondria. In vivo results were consistent with those observed in vitro. The parasitic load was significantly lower than in the control assay with benznidazole. The effects of these products showed the reduction of the anti-T. cruzi antibodies level during the chronic stage.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Neglected Tropical Diseases Network
PubMed ID: 22802442
Web of Science ID: 308680100017
URI: http://researchonline.lshtm.ac.uk/id/eprint/2907068

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