Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite.


Santos, JM; Duarte, N; Kehrer, J; Ramesar, J; Avramut, MC; Koster, AJ; Dessens, JT; Frischknecht, F; Chevalley-Maurel, S; Janse, CJ; Franke-Fayard, B; Mair, GR; (2016) Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite. Proceedings of the National Academy of Sciences of the United States of America, 113 (26). pp. 7183-8. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.1522381113

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Abstract

: Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and stage-specific organelles. Here we show that formation of the crystalloid-a unique and short-lived organelle of the Plasmodium ookinete and oocyst stage required for sporogony-is dependent on the precisely timed expression of the S-acyl-transferase DHHC10. DHHC10, translationally repressed in female Plasmodium berghei gametocytes, is activated translationally during ookinete formation, where the protein is essential for the formation of the crystalloid, the correct targeting of crystalloid-resident protein LAP2, and malaria parasite transmission.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 27303037
Web of Science ID: 379033400062
URI: http://researchonline.lshtm.ac.uk/id/eprint/2551416

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