Glycophorins, Blood Groups, and Protection from Severe Malaria.


Wassmer, SC; Carlton, JM; (2015) Glycophorins, Blood Groups, and Protection from Severe Malaria. Trends in parasitology, 32 (1). pp. 5-7. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2015.11.006

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Abstract

In Malaŵi, Malungo alibe odi is a saying that translates as: 'Malaria does not ask permission before coming in'. The recent finding of a new severe malaria resistance locus next to a cluster of glycophorin genes involved in Plasmodium falciparum erythrocyte invasion seems to suggest otherwise: that evolutionary pressure is enabling erythrocytes to lock the door to keep malaria out.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
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PubMed ID: 26613665
Web of Science ID: 368206900004
URI: http://researchonline.lshtm.ac.uk/id/eprint/2548732

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